C-reactive protein as a biomarker of severe H1N1 influenza.

ABSTRACT:

Background

C-reactive protein (CRP) is an acute-phase reactant downstream of the pro-inflammatory cytokines released during influenza infection. However, the role of this inflammatory marker in influenza severity and complications is yet to be elucidated.

Objectives

We aim to systematically review and evaluate the levels of CRP in severe and non-severe H1N1 influenza cases and assess its utility as a biomarker in predicting the severity of infection.

Methods

We conducted a comprehensive search in Ovid MEDLINE, Ovid MEDLINE (R) Epub ahead of Print, Embase and Embase Classic to identify human studies reporting measurements of CRP levels in patients infected with H1N1 influenza at various levels of disease severity.

Results

Our search identified ten studies eligib

SUBMITTER: Vasileva D 

PROVIDER: S-EPMC6314979 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature