The clinical implications of FDG-PET/CT differ according to histology in advanced gastric cancer.

ABSTRACT:

Background

The prognostic impact of preoperative ¹⁸F-FDG PET/CT in advanced gastric cancer (AGC) remains a matter of debate. This study aims to evaluate the prognostic impact of SUV_max in preoperative ¹⁸F-FDG PET/CT of AGC according to histologic subtype, with a focus on the differences between tubular adenocarcinoma and signet ring cell (SRC) carcinoma.

Methods

As a discovery set, a total of 727 AGC patients from prospective database were analyzed according to histologic subtype with Cox proportional hazard model and p-spline curves. In addition, another 173 patients from an independent institution was assessed as an external validation set.

Results

In multivariate analysis, high SUV_max in preoperative ¹⁸F-FDG PE

SUBMITTER: Chon HJ 

PROVIDER: S-EPMC6314995 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature