Hydrogen Sulfide Attenuates Renin Angiotensin and Aldosterone Pathological Signaling to Preserve Kidney Function and Improve Exercise Tolerance in Heart Failure.

ABSTRACT: Cardioprotective effects of H₂S have been well documented. However, the lack of evidence supporting the benefits afforded by delayed H₂S therapy warrants further investigation. Using a murine model of transverse aortic constriction-induced heart failure, this study showed that delayed H₂S therapy protects multiple organs including the heart, kidney, and blood-vessel; reduces oxidative stress; attenuates renal sympathetic and renin-angiotensin-aldosterone system pathological activation; and ultimately improves exercise capacity. These findings provide further insights into H₂S-mediated cardiovascular protection and implicate the benefits of using H₂S-based therapies clinically for the treatment of heart failure.

SUBMITTER: Li Z 

PROVIDER: S-EPMC6315048 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature