Ontology highlight
ABSTRACT:
SUBMITTER: Commerford CD
PROVIDER: S-EPMC6315107 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Cell reports 20181201 13
Enlargement of the lymphatic vascular network in tumor-draining lymph nodes (LNs) often precedes LN metastasis, likely providing a lymphovascular niche for tumor cells. We investigated morphological and molecular changes associated with the lymphatic remodeling process, using the 4T1 breast cancer and B16F10 melanoma models. Lymphatic expansion in tumor-draining LNs is mediated by sprouting and proliferation of lymphatic endothelial cells (LECs) as early as 4 days after tumor implantation. RNA s ...[more]