Apolipoprotein E Overexpression Is Associated With Tumor Progression and Poor Survival in Colorectal Cancer.

ABSTRACT: Apolipoprotein E (ApoE) plays a key role in tumorigenesis and progression, such as cell proliferation, angiogenesis and metastasis. ApoE overexpression was associated with aggressive biological behaviors and poor prognosis in a variety of tumor according to previous studies. This study aimed to assess the prognostic value and explore the potential relationship with tumor progression in colorectal cancer (CRC). We collected the expression profiling microarray data from the Gene Expression Omnibus (GEO), investigated the ApoE expression pattern between the primary CRC and liver metastasis of CRC, and then explored the gene with prognostic significance based on the TCGA database. ApoE high expression was associated with poor overall survival (OS, p =

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC6315167 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature