Glabridin triggers over-expression of apoptosis inducing factor (AIF) gene in Candida albicans.

ABSTRACT:

Background and purpose

Candida albicans is a prevalent human fungal pathogen that can cause a wide spectrum of diseases, from superficial mucosal infections to systemic disorders, in patients with impaired immunity. Glabridin is a pyranoisoflavan originally extracted from root extract of Glycyrrhiza glabra. Glabridin can also mediate apoptosis in yeast cells by changing the mitochondrial membrane potential, activation of caspase-like proteases, and DNA cleavage. The aim of this study was to investigate the mechanism of action of glabridin in C. albicans.

Materials and methods

Candida albicans ATCC14053 was applied as the standard strain. Total RNA was extracted from the isolate under glabridin-treated and untreated conditions. To evaluate the alte

SUBMITTER: Moazeni M 

PROVIDER: S-EPMC6315205 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature