A Systematic Overview of Type II and III Toxin-Antitoxin Systems with a Focus on Druggability.

ABSTRACT: Toxin-antitoxin (TA) systems are known to play various roles in physiological processes, such as gene regulation, growth arrest and survival, in bacteria exposed to environmental stress. Type II TA systems comprise natural complexes consisting of protein toxins and antitoxins. Each toxin and antitoxin participates in distinct regulatory mechanisms depending on the type of TA system. Recently, peptides designed by mimicking the interfaces between TA complexes showed its potential to activate the activity of toxin by competing its binding counterparts. Type II TA systems occur more often in pathogenic bacteria than in their nonpathogenic kin. Therefore, they can be possible drug targets, because of their high abundance in some pathogenic bacteria, such as Mycobacterium tuberculosis. In addit

SUBMITTER: Kang SM 

PROVIDER: S-EPMC6315513 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature