Pre-Ribosomal RNA Processing in Human Cells: From Mechanisms to Congenital Diseases.

ABSTRACT: Ribosomal RNAs, the most abundant cellular RNA species, have evolved as the structural scaffold and the catalytic center of protein synthesis in every living organism. In eukaryotes, they are produced from a long primary transcript through an intricate sequence of processing steps that include RNA cleavage and folding and nucleotide modification. The mechanisms underlying this process in human cells have long been investigated, but technological advances have accelerated their study in the past decade. In addition, the association of congenital diseases to defects in ribosome synthesis has highlighted the central place of ribosomal RNA maturation in cell physiology regulation and broadened the interest in these mechanisms. Here, we give an overview of the current knowledge of pre-ribosomal

SUBMITTER: Aubert M 

PROVIDER: S-EPMC6315592 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature