Dietary Advanced Glycation Endproducts Induce an Inflammatory Response in Human Macrophages in Vitro.

ABSTRACT: Advanced glycation endproducts (AGEs) can be found in protein- and sugar-rich food products processed at high temperatures, which make up a vast amount of the Western diet. The effect of AGE-rich food products on human health is not yet clear and controversy still exists due to possible contamination of samples with endotoxin and the use of endogenous formed AGEs. AGEs occur in food products, both as protein-bound and individual molecules. Which form exactly induces a pro-inflammatory effect is also unknown. In this study, we exposed human macrophage-like cells to dietary AGEs, both in a protein matrix and individual AGEs. It was ensured that all samples did not contain endotoxin concentrations > 0.06 EU/mL. The dietary AGEs induced TNF-alpha secretion of human macrophage-like cells. This

SUBMITTER: van der Lugt T 

PROVIDER: S-EPMC6315629 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature