A Marine Diterpenoid Modulates the Proteasome Activity in Murine Macrophages Stimulated with LPS.

ABSTRACT: The proteasome is an intracellular complex that degrades damaged or unfolded proteins and participates in the regulation of several processes. The immunoproteasome is a specialized form that is expressed in response to proinflammatory signals and is particularly abundant in immune cells. In a previous work, we found an anti-inflammatory effect in a diterpenoid extracted from the octocoral Pseudopterogorgia acerosa, here called compound 1. This compound prevented the degradation of inhibitor κB α (IκBα) and the subsequent activation of nuclear factor κB (NFκB), suggesting that this effect might be due to inhibition of the ubiquitin-proteasome system. Here we show that compound 1 inhibits the proteasomal chymotrypsin-like activity (CTL) of murine macrophages in the presence of lipopol

SUBMITTER: Gonzalez Y 

PROVIDER: S-EPMC6315684 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature