Established and Emerging Concepts to Treat Imbalances of Iron Homeostasis in Inflammatory Diseases.

ABSTRACT: Inflammation, being a hallmark of many chronic diseases, including cancer, inflammatory bowel disease, rheumatoid arthritis, and chronic kidney disease, negatively affects iron homeostasis, leading to iron retention in macrophages of the mononuclear phagocyte system. Functional iron deficiency is the consequence, leading to anemia of inflammation (AI). Iron deficiency, regardless of anemia, has a detrimental impact on quality of life so that treatment is warranted. Therapeutic strategies include (1) resolution of the underlying disease, (2) iron supplementation, and (3) iron redistribution strategies. Deeper insights into the pathophysiology of AI has led to the development of new therapeutics targeting inflammatory cytokines and the introduction of new iron formulations. Moreover, the dis

SUBMITTER: Petzer V 

PROVIDER: S-EPMC6315795 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature