Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.

ABSTRACT: Influenza A viruses (IAV) can infect a broad range of animal hosts, including humans. In humans, IAV causes seasonal annual epidemics and occasional pandemics, representing a serious public health and economic problem, which is most effectively prevented through vaccination. The defense mechanisms that the host innate immune system provides restrict IAV replication and infection. Consequently, to successfully replicate in interferon (IFN)-competent systems, IAV has to counteract host antiviral activities, mainly the production of IFN and the activities of IFN-induced host proteins that inhibit virus replication. The IAV multifunctional proteins PA-X and NS1 are virulence factors that modulate the innate immune response and virus pathogenicity. Notably, these two viral proteins have synergi

SUBMITTER: Nogales A 

PROVIDER: S-EPMC6315843 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature