Pattern of Paracetamol Poisoning: Influence on Outcome and Complications.

ABSTRACT: Acute paracetamol poisoning due to a single overdose may be effectively treated by the early administration of N-acetylcysteine (NAC) as an antidote. The prognosis may be different in the case of intoxication due to multiple ingestions or when the antidote is started with delay. The aim of this work was to investigate the outcome of paracetamol poisoning according to the pattern of ingestion and determine the factors associated with the outcome. We performed a retrospective analysis over the period 2007⁻2017 of the patients who were referred to a tertiary hospital for paracetamol-related hepatotoxicity. Inclusion criteria were: accidental or voluntary ingestion of paracetamol, delay for NAC therapy of 12 h or more, liver enzymes (ALT) >1000 IU/L on admission. Ninety patients were considere

SUBMITTER: Castanares-Zapatero D 

PROVIDER: S-EPMC6315900 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature