Combining Dietary Sulfur Amino Acid Restriction with Polyunsaturated Fatty Acid Intake in Humans: A Randomized Controlled Pilot Trial.

ABSTRACT: Dietary and plasma total cysteine (tCys) have been associated with adiposity, possibly through interaction with stearoyl⁻CoA desaturase (SCD), which is an enzyme that is involved in fatty acid and energy metabolism. We evaluated the effect of a dietary intervention with low cysteine and methionine and high polyunsaturated fatty acids (PUFAs) on plasma and urinary sulfur amino acids and SCD activity indices. Fourteen normal-weight healthy subjects were randomized to a seven-day diet low in cysteine and methionine and high in PUFAs (Cys/Met_low + PUFA), or high in saturated fatty acids (SFA), cysteine, and methionine (Cys/Met_high + SFA). Compared with the Cys/Met_high + SFA group, plasma methionine and cystathionine decreased (p-values < 0.05), whereas c

SUBMITTER: Olsen T 

PROVIDER: S-EPMC6315936 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature