Clogging the Ubiquitin-Proteasome Machinery with Marine Natural Products: Last Decade Update.

ABSTRACT: The ubiquitin-proteasome pathway (UPP) is the central protein degradation system in eukaryotic cells, playing a key role in homeostasis maintenance, through proteolysis of regulatory and misfolded (potentially harmful) proteins. As cancer cells produce proteins inducing cell proliferation and inhibiting cell death pathways, UPP inhibition has been exploited as an anticancer strategy to shift the balance between protein synthesis and degradation towards cell death. Over the last few years, marine invertebrates and microorganisms have shown to be an unexhaustive factory of secondary metabolites targeting the UPP. These chemically intriguing compounds can inspire clinical development of novel antitumor drugs to cope with the incessant outbreak of side effects and resistance mechanisms induced

SUBMITTER: Della Sala G 

PROVIDER: S-EPMC6316072 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature