High-Frequency Microdomain Ca²⁺ Transients and Waves during Early Myelin Internode Remodeling.

ABSTRACT: Ensheathment of axons by myelin is a highly complex and multi-cellular process. Cytosolic calcium (Ca²⁺) changes in the myelin sheath have been implicated in myelin synthesis, but the source of this Ca²⁺ and the role of neuronal activity is not well understood. Using one-photon Ca²⁺ imaging, we investigated myelin sheath formation in the mouse somatosensory cortex and found a high rate of spontaneous microdomain Ca²⁺ transients and large-amplitude Ca²⁺ waves propagating along the internode. The frequency of Ca²⁺ transients and waves rapidly declines with maturation and reactivates during remyelination. Unexpectedly, myelin microdomain Ca²⁺ transients occur independent of neuronal action potential generation or net

SUBMITTER: Battefeld A 

PROVIDER: S-EPMC6316190 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature