Bromopyrrole Alkaloids from the Sponge Agelas kosrae.

ABSTRACT: Two new sceptrin derivatives (1,2) and eight structurally-related known bromopyrrole-bearing alkaloids were isolated from the tropical sponge Agelas kosrae. By a combination of spectroscopic methods, the new compounds, designated dioxysceptrin (1) and ageleste C (2), were determined to be structural analogs of each other that differ at the imidazole moiety. Dioxysceptrin was also found to exist as a mixture of α-amido epimers. The sceptrin alkaloids exhibited weak cytotoxicity against cancer cells. Compounds 1 and 2 also moderately exhibited anti-angiogenic and isocitrate lyase-inhibitory activities, respectively.

SUBMITTER: Kwon OS 

PROVIDER: S-EPMC6316234 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature