Ancient Ancestry Informative Markers for Identifying Fine-Scale Ancient Population Structure in Eurasians.

ABSTRACT: The rapid accumulation of ancient human genomes from various areas and time periods potentially enables the expansion of studies of biodiversity, biogeography, forensics, population history, and epidemiology into past populations. However, most ancient DNA (aDNA) data were generated through microarrays designed for modern-day populations, which are known to misrepresent the population structure. Past studies addressed these problems by using ancestry informative markers (AIMs). It is, thereby, unclear whether AIMs derived from contemporary human genomes can capture ancient population structures, and whether AIM-finding methods are applicable to aDNA, provided that the high missingness rates in ancient-and oftentimes haploid-DNA can also distort the population structure. Here, we define anc

SUBMITTER: Esposito U 

PROVIDER: S-EPMC6316245 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature