New Perspectives in Iron Chelation Therapy for the Treatment of Neurodegenerative Diseases.

ABSTRACT: Iron chelation has been introduced as a new therapeutic concept for the treatment of neurodegenerative diseases with features of iron overload. At difference with iron chelators used in systemic diseases, effective chelators for the treatment of neurodegenerative diseases must cross the blood⁻brain barrier. Given the promissory but still inconclusive results obtained in clinical trials of iron chelation therapy, it is reasonable to postulate that new compounds with properties that extend beyond chelation should significantly improve these results. Desirable properties of a new generation of chelators include mitochondrial destination, the center of iron-reactive oxygen species interaction, and the ability to quench free radicals produced by the Fenton reaction. In addition, these chelators

SUBMITTER: Nunez MT 

PROVIDER: S-EPMC6316457 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature