A New Role for Vitamin D: The Enhancement of Oncolytic Viral Therapy in Pancreatic Cancer.

ABSTRACT: Oncolytic viruses have emerged as a novel class of anti-cancer therapeutics with one virus already receiving United States Food and Drug Administration (FDA) approval (talimogene laherparepvec) and many others undergoing testing in clinical trials. These viruses have direct lytic effects on tumor cells as well as immunomodulatory functions to increase inflammatory cell infiltrates in the tumor microenvironment. Despite all of the advances in cancer care, pancreatic cancer remains a highly lethal malignancy. One of the main barriers to successful systemic treatment of the disease is the fibrotic tumor stroma, as the unique extracellular matrix creates an environment that promotes tumor growth and is resistant to chemotherapy and other anti-cancer agents. The pleiotropic effects of Vitamin D

SUBMITTER: LaRocca CJ 

PROVIDER: S-EPMC6316500 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature