Effect of Surface Coating of Gold Nanoparticles on Cytotoxicity and Cell Cycle Progression.

ABSTRACT: Gold nanoparticles (GNPs) are usually wrapped with biocompatible polymers in biomedical field, however, the effect of biocompatible polymers of gold nanoparticles on cellular responses are still not fully understood. In this study, GNPs with/without polymer wrapping were used as model probes for the investigation of cytotoxicity and cell cycle progression. Our results show that the bovine serum albumin (BSA) coated GNPs (BSA-GNPs) had been transported into lysosomes after endocytosis. The lysosomal accumulation had then led to increased binding between kinesin 5 and microtubules, enhanced microtubule stabilization, and eventually induced G₂/M arrest through the regulation of cadherin 1. In contrast, the bare GNPs experienced lysosomal escape, resulting in microtubule damage and G₀/G₁ arres

SUBMITTER: Li Q 

PROVIDER: S-EPMC6316730 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature