Quantifying promoter-specific Insulin-like Growth Factor 1 gene expression by interrogating public databases.

ABSTRACT: The actions of insulin-like growth factor 1 (IGF1), a small, secreted protein, are essential for normal somatic growth in children and are important for tissue regeneration and repair in adults. Similar functions are conserved in other mammalian species. IGF1 gene regulation is complicated in mammals, with transcription being controlled by different hormonal, nutritional, and tissue-specific inputs. Quantifying IGF1 gene expression in different organs and tissues also has been difficult because of the variable contributions of its two promoters and because of the lack of standard platforms for analysis. Here, I have taken advantage of the wealth of information found in publicly accessible RNA-sequencing libraries to measure steady-state levels of IGF1 mRNAs from human and macaque, species

SUBMITTER: Rotwein P 

PROVIDER: S-EPMC6317063 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature