A Network Pharmacology Approach to Uncover the Potential Mechanism of Yinchensini Decoction.

ABSTRACT:

Objective

To predict and explore the potential mechanism of Yinchensini decoction (YCSND) based on systemic pharmacology.

Method

TCMSP database was searched for the active constituents and related target proteins of YCSND. Cytoscape 3.5.1 was used to construct the active ingredient-target interaction of YCSND and network topology analysis, with STRING online database for protein-protein interaction (PPI) network construction and analysis; and collection from the UniProt database of target protein gene name, with the DAVID database for the gene ontology (GO) functional analysis, KEGG pathway enrichment analysis mechanism and targets of YCSND.

Results

The results indicate the core compounds of YCSND, namely, kaempferol, 7-Methoxy-2-methyl isoflavone, and formononetin. A

SUBMITTER: Chen G 

PROVIDER: S-EPMC6317126 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature