Possible involvement of peripheral TRP channels in the hydrogen sulfide-induced hyperalgesia in diabetic rats.

ABSTRACT:

Background

Peripheral diabetic neuropathy can be painful and its symptoms include hyperalgesia, allodynia and spontaneous pain. Hydrogen sulfide (H₂S) is involved in diabetes-induced hyperalgesia and allodynia. However, the molecular target through which H₂S induces hyperalgesia in diabetic animals is unclear. The aim of this study was to determine the possible involvement of transient receptor potential (TRP) channels in H₂S-induced hyperalgesia in diabetic rats.

Results

Streptozotocin (STZ) injection produced hyperglycemia in rats. Intraplantar injection of NaHS (an exogenous donor of H₂S, 3-100 µg/paw) induced hyperalgesia, in a time-dependent manner, in formalin-treated diabetic rats. NaHS-induced hyperalgesia was partially pre

SUBMITTER: Roa-Coria JE 

PROVIDER: S-EPMC6317195 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature