Outcomes following second allogeneic stem cell transplant for disease relapse after T cell depleted transplant correlate with remission status and remission duration after the first transplant.

ABSTRACT:

Background

Second allogeneic hematopoietic stem cell transplant (HCT) remains as an option for disease relapse after initial HCT.

Methods

We analyzed retrospectively the outcomes of 65 consecutive patients who underwent a second HCT for disease relapse at the University of Chicago. Univariate and multivariate analysis were conducted, and a scoring system was generated to select the patients who would benefit second HCT.

Results

All except four patients received T cell depleted (TCD) first HCT. The majority of patients had AML (n = 47) and high risk MDS (n = 5). The median age at second HCT was 45 years (11-73). 13 patients (20%) achieved CR before second HCT. 98% (n = 64) and 72% (n = 47) patients achieved neutrophil and platelet engraftment at a median interval of 10

SUBMITTER: Fan Y 

PROVIDER: S-EPMC6317199 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature