Is Saglin a mosquito salivary gland receptor for Plasmodium falciparum?

ABSTRACT:

Background

Saglin, a 100 kDa protein composed of two 50 kDa homodimers, is present in the salivary glands of Anopheles gambiae and has been considered an essential receptor for sporozoites (SPZ) of Plasmodium berghei and Plasmodium falciparum (Pf), allowing SPZ to recognize, bind to, and infect mosquito salivary glands. Spatial and temporal patterns of Saglin expression reported here, however, suggest that this model does not fully describe the Saglin-SPZ interaction.

Results

Saglin protein was detected by indirect immunofluorescence microscopy only in the medial and proximal-lateral lobes, but not in the distal-lateral lobes, of the salivary glands of An. gambiae; the pattern of expression was independent of mosquito age or physiological state. These results were confirmed

SUBMITTER: O'Brochta DA 

PROVIDER: S-EPMC6317240 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature