Graphene oxide down-regulates genes of the oxidative phosphorylation complexes in a glioblastoma.

ABSTRACT:

Background

Recently different forms of nanographene were proposed as the material with high anticancer potential. However, the mechanism of the suppressive activity of the graphene on cancer development remains unclear. We examined the effect of oxygenated, reduced and pristine graphene on the gene expression in glioblastoma U87 cell line.

Results

Conducting microarrays and RT-qPCR analysis we explored that graphene oxide (rather than reduced graphene oxide and pristine graphene) down-regulates the mRNA expression of mitochondrial oxidative phosphorylation (OXPHOS) nuclear genes of complexes I, III, IV and V. The presented results provide first evidence for the hypothesis that the suppressed growth of GBM can be the consequence of down-regulation of OXPHOS protein expression

SUBMITTER: Szmidt M 

PROVIDER: S-EPMC6317254 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature