Ancient convergent losses of Paraoxonase 1 yield potential risks for modern marine mammals.

ABSTRACT: Mammals diversified by colonizing drastically different environments, with each transition yielding numerous molecular changes, including losses of protein function. Though not initially deleterious, these losses could subsequently carry deleterious pleiotropic consequences. We have used phylogenetic methods to identify convergent functional losses across independent marine mammal lineages. In one extreme case, Paraoxonase 1 (PON1) accrued lesions in all marine lineages, while remaining intact in all terrestrial mammals. These lesions coincide with PON1 enzymatic activity loss in marine species' blood plasma. This convergent loss is likely explained by parallel shifts in marine ancestors' lipid metabolism and/or bloodstream oxidative environment affecting PON1's role in fatty

SUBMITTER: Meyer WK 

PROVIDER: S-EPMC6317340 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature