Latent class analysis of ARDS subphenotypes: a secondary analysis of the statins for acutely injured lungs from sepsis (SAILS) study.

ABSTRACT:

Purpose

Using latent class analysis (LCA), we have consistently identified two distinct subphenotypes in four randomized controlled trial cohorts of ARDS. One subphenotype has hyper-inflammatory characteristics and is associated with worse clinical outcomes. Further, within three negative clinical trials, we observed differential treatment response by subphenotype to randomly assigned interventions. The main purpose of this study was to identify ARDS subphenotypes in a contemporary NHLBI Network trial of infection-associated ARDS (SAILS) using LCA and to test for differential treatment response to rosuvastatin therapy in the subphenotypes.

Methods

LCA models were constructed using a combination of biomarker and clinical data at baseline in the SAILS study (n = 745). LCA mode

SUBMITTER: Sinha P 

PROVIDER: S-EPMC6317524 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature