Investigating the Relationship between Cerebral Blood Flow and Cognitive Function in Hemodialysis Patients.

ABSTRACT:

Background

The immediate and longer-term effects of hemodialysis on cerebral circulation, cerebral structure, and cognitive function are poorly understood.

Methods

In a prospective observational cohort study of 97 adults (median age 59 years) receiving chronic hemodialysis, we used transcranial Doppler ultrasound to measure cerebral arterial mean flow velocity (MFV) throughout dialysis. Using a well validated neuropsychological protocol, we assessed cognitive function during and off dialysis and after 12 months of treatment. We also used brain magnetic resonance imaging (MRI) to assess atrophy, white matter hyperintensities (WMHs), and diffusion parameters, and tested correlations between MFV, cognitive scores, and changes on MRI.

Results

MFV declined significantly du

SUBMITTER: Findlay MD 

PROVIDER: S-EPMC6317612 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature