MiR‑122 promotes proliferation and invasion of clear cell renal cell carcinoma by suppressing Forkhead box O3.

ABSTRACT: MicroRNAs (miRNAs) serve an important role in renal cancer, but renal cancer miRNA expression data remains inconsistent. Therefore, there is a requirement for integrated analysis of these data. An increasing number of studies demonstrate that miR‑122 is dysregulated in numerous cancer types, including liver, lung and breast cancer, yet its role in clear cell renal cell carcinoma (ccRCC) remains unclear. In the present study, an integrated analysis of four ccRCC miRNAs expression datasets was performed and the expression of miR‑122 in the present cohort was validated. The effects of cell proliferation, colony formation, migration and invasion of ccRCC cells in vitro were assayed following transfection with miR‑122 mimics and inhibitor. The target gene of miR‑122 was confirmed using a lucife

SUBMITTER: Nie W 

PROVIDER: S-EPMC6317650 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature