Melatonin regulation of transcription in the reversal of morphine tolerance: Microarray analysis of differential gene expression.

ABSTRACT: Tolerance and associated hyperalgesia induced by long‑term morphine administration substantially restrict the clinical use of morphine in pain treatment. Melatonin, a neurohormone released by the pineal gland, has been demonstrated to attenuate anti‑nociceptive morphine tolerance. The present study investigates differentially expressed genes in the process of morphine tolerance and altered gene expression subsequent to melatonin treatment in chronic morphine‑infused ratspinal cords. Morphine tolerance was induced in male Wistar rats by intrathecal morphine infusion (the MO group). Melatonin (the MOMa group) was administered to overcome the effects derived by morphine. The mRNA collected from L5‑S3 of the spinal cord was extracted and analysed by rat expression microarray. Principal compone

SUBMITTER: Cheng YC 

PROVIDER: S-EPMC6317689 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature