Deconstructive diversification of cyclic amines.

ABSTRACT: Deconstructive functionalization involves carbon-carbon (C-C) bond cleavage followed by bond construction on one or more of the constituent carbons. For example, ozonolysis¹ and olefin metathesis^2,3 have allowed each carbon in C=C double bonds to be viewed as a functional group. Despite the substantial advances in deconstructive functionalization involving the scission of C=C double bonds, there are very few methods that achieve C(sp³)-C(sp³) single-bond cleavage and functionalization, especially in relatively unstrained cyclic systems. Here we report a deconstructive strategy to transform saturated nitrogen heterocycles such as piperidines and pyrrolidines, which are important moieties in bioactive molecules, into halogen-containing acyclic amin

SUBMITTER: Roque JB 

PROVIDER: S-EPMC6317721 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature