Mupirocin for Staphylococcus aureus Decolonization of Infants in Neonatal Intensive Care Units.

ABSTRACT: : media-1vid110.1542/5849573989001PEDS-VA_2018-1565Video Abstract BACKGROUND AND OBJECTIVES: Staphylococcus aureus (SA) is the second leading cause of late-onset sepsis among infants in the NICU. Because colonization of nasal mucosa and/or skin frequently precedes invasive infection, decolonization strategies, such as mupirocin application, have been attempted to prevent clinical infection, but data supporting this approach in infants are limited. We conducted a phase 2 multicenter, open-label, randomized trial to assess the safety and efficacy of intranasal plus topical mupirocin in eradicating SA colonization in critically ill infants.

Methods

Between April 2014 and May 2016, infants <24 months old in the NICU at 8 study centers underwent serial screening for nasal S

SUBMITTER: Kotloff KL 

PROVIDER: S-EPMC6317770 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature