The influence of obesity-related factors in the etiology of renal cell carcinoma-A mendelian randomization study.

ABSTRACT:

Background

Several obesity-related factors have been associated with renal cell carcinoma (RCC), but it is unclear which individual factors directly influence risk. We addressed this question using genetic markers as proxies for putative risk factors and evaluated their relation to RCC risk in a mendelian randomization (MR) framework. This methodology limits bias due to confounding and is not affected by reverse causation.

Methods and findings

Genetic markers associated with obesity measures, blood pressure, lipids, type 2 diabetes, insulin, and glucose were initially identified as instrumental variables, and their association with RCC risk was subsequently evaluated in a genome-wide association study (GWAS) of 10,784 RCC patients and 20,406 control participants in a 2-sampl

SUBMITTER: Johansson M 

PROVIDER: S-EPMC6317776 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature