Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS2.

ABSTRACT:

Background

Efforts to promote the cessation of harmful alcohol use are hindered by the affective and physiological components of alcohol withdrawal (AW), which can include life-threatening seizures. Although previous studies of AW and relapse have highlighted the detrimental role of stress, little is known about genetic risk factors.

Methods

We conducted a genome-wide association study of AW symptom count in uniformly assessed subjects with histories of serious AW, followed by additional genotyping in independent AW subjects.

Results

The top association signal for AW severity was in sortilin family neurotrophin receptor gene SORCS2 on chromosome 4 (European American meta-analysis n = 1,478, p = 4.3 × 10^-9 ). There were no genome-wide significant findings in

SUBMITTER: Smith AH 

PROVIDER: S-EPMC6317871 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature