Pyruvate secreted from patient-derived cancer-associated fibroblasts supports survival of primary lymphoma cells.

ABSTRACT: Cancer-associated fibroblasts (CAF) are a key component in the tumor microenvironment and play functional roles in tumor metastasis and resistance to chemotherapies. We have previously reported that CAF isolated from lymphoma samples increase anaerobic glycolysis and decrease intracellular production of reactive oxygen species, promoting the survival of tumor cells. Herein, we analyzed the mechanisms underlying this support of tumor-cell survival by CAF. As direct contact between lymphoma cells and CAF was not indispensable to survival support, we identified that the humoral factor pyruvate was significantly secreted by CAF. Moreover, survival of lymphoma cells was promoted by the presence of pyruvate, and this promotion was canceled by inhibition of monocarboxylate transporters. Metabolom

SUBMITTER: Sakamoto A 

PROVIDER: S-EPMC6317936 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature