Central neuroimmune activity and depressive-like behavior in response to repeated maternal separation and injection of LPS.

ABSTRACT: Disruption of attachment relations in early life is linked to greater vulnerability to depressive illness at later ages. Evidence suggests this process involves stress-induced activation of central inflammatory factors, though the specific mediators and processes involved are not known. We used a guinea pig model in which effects of maternal separation appear more clearly due to absence of the attachment figure than is the case for other laboratory rodents. Separation in a novel environment on two consecutive days evoked a depressive-like behavioral response that sensitized during a final test 9 days later. At this time, prior separation blunted the response of prostaglandin synthesizing enzymes (COX-2 and mPGES) and chemokines (CXCL-1 and MCP-1) 120 min following injection with lipopolysa

SUBMITTER: Hennessy MB 

PROVIDER: S-EPMC6317968 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature