A Computational Cardiac Model for the Adaptation to Pulmonary Arterial Hypertension in the Rat.

ABSTRACT: Pulmonary arterial hypertension (PAH) imposes pressure overload on the right ventricle (RV), leading to RV enlargement via the growth of cardiac myocytes and remodeling of the collagen fiber architecture. The effects of these alterations on the functional behavior of the right ventricular free wall (RVFW) and organ-level cardiac function remain largely unexplored. Computational heart models in the rat (RHMs) of the normal and hypertensive states can be quite valuable in simulating the effects of PAH on cardiac function to gain insights into the pathophysiology of underlying myocardium remodeling. We thus developed high-fidelity biventricular finite element RHMs for the normal and post-PAH hypertensive states using extensive experimental data collected from rat hearts. We then applied the R

SUBMITTER: Avazmohammadi R 

PROVIDER: S-EPMC6318016 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature