Mammary Precancerous Stem and Non-Stem Cells Evolve into Cancers of Distinct Subtypes.

ABSTRACT: There are distinct cell subpopulations in normal epithelial tissue, including stem cells, progenitor cells, and more differentiated cells, all of which have been extensively studied for their susceptibility to tumorigenesis. However, normal cells usually have to progress through a precancerous lesion state before becoming a full-blown tumor. Precancerous early lesions are heterogeneous, and the cell subset that is the primary source of the eventual tumor remains largely unknown. By using mouse models that are tailored to address this question, we identified a keratin 6a-expressing precancerous stem cell (PcSC) subset and a more differentiated whey acidic protein-positive (WAP+) cell subset in mammary precancerous lesions initiated by the Wnt1 oncogene. Both cell subsets rapidly prog

SUBMITTER: Bu W 

PROVIDER: S-EPMC6318055 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature