Gray Matter Volume Reductions Were Associated with TPH1 Polymorphisms in Depressive Disorder Patients with Suicidal Attempts.

ABSTRACT:

Objective

Structural changes of brain areas have been reported in depressive disorder and suicidal behavior (SB), in which TPH1 also has been known as a promising candidate gene. We investigated gray matter volume (GMV) differences, TPH1 rs1800532 and rs1799913 polymorphisms previously found to be associated with depressive disorder and SB, and the relationship between the two markers.

Methods

Thirteen depressive disorder patients with suicidal attempts (SA) and twenty healthy controls were included. We examined GMV differences using a voxel-based morphometry and regions of interest analysis. Direct sequencing was used for genotyping.

Results

The patients showed significant GMV reduction in left cerebral region including middle frontal gyrus, inferior frontal gyrus, a

SUBMITTER: Lee SM 

PROVIDER: S-EPMC6318492 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature