Comparison of the efficacy and safety of drug therapies for macular edema secondary to central retinal vein occlusion.

ABSTRACT:

Objectives

To evaluate the efficacy and safety of anti-vascular endothelial growth factor (VEGF) agents and corticosteroids for the treatment of macular oedema (ME) secondary to central retinal vein occlusion (CRVO).

Design

Systematic review and network meta-analysis.

Participants

Patients from previously reported randomised controlled trials (RCTs) comparing anti-VEGF and corticosteroids for the treatment of ME secondary to CRVO.

Methods

Literature searches were conducted using PubMed, Medline, Embase, Cochrane Library and clinicaltrials.gov until March 2017. Therapeutic effects were estimated using the proportions of patients gaining/losing ≥15 letters, best-corrected visual acuity (BCVA) and central retinal thickness (CRT). Treatment safety was estimated usi

SUBMITTER: Qian T 

PROVIDER: S-EPMC6318534 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature