Highly Thiolated Poly (Beta-Amino Ester) Nanoparticles for Acute Redox Applications.

ABSTRACT: Disulfides are used extensively in reversible cross-linking because of the ease of reduction into click-reactive thiols. However, the free-radical scavenging properties upon reduction are often under-considered. The free thiols produced upon reduction of this disulfide material mimic the cellular reducing chemistry (glutathione) that serves as a buffer against acute oxidative stress. A nanoparticle formulation producing biologically relevant concentrations of thiols may not only provide ample chemical conjugation sites, but potentially be useful against severe acute oxidative stress exposure, such as in targeted radioprotection. In this work, we describe the synthesis and characterization of highly thiolated poly (β-amino ester) (PBAE) nanoparticles formed from the reduction of bulk disulf

SUBMITTER: Lakes AL 

PROVIDER: S-EPMC6318580 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature