Identification of therapeutic targets in chordoma through comprehensive genomic and transcriptomic analyses.

ABSTRACT: Chordoma is a rare, orphan cancer arising from embryonal precursors of bone. Surgery and radiotherapy (RT) provide excellent local control, often at the price of significant morbidity because of the structures involved and the need for relatively high doses of RT; however, recurrence remains high. Although our understanding of the genetic changes that occur in chordoma is evolving rapidly, this knowledge has yet to translate into treatments. We performed comprehensive DNA (paired tumor/normal whole-exome and shallow whole-genome) and RNA (tumor whole-transcriptome) next-generation sequencing analyses of archival sacral and clivus chordoma specimens. Incorporation of transcriptomic data enabled the identification of gene overexpression and expressed DNA alterations, thus providing additiona

SUBMITTER: Liang WS 

PROVIDER: S-EPMC6318766 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature