Changes in antimicrobial susceptibility profiles of Mycoplasma bovis over time.

ABSTRACT: Mycoplasma bovis is a major cause of pneumonia, arthritis, and mastitis in cattle and can lead to significant economic losses. Antimicrobial resistance is a concern and further limits the already short list of drugs effective against mycoplasmas. The objective of this study was to examine changes in in vitro minimum inhibitory concentrations (MICs) of antimicrobials of aminoglycoside, fluoroquinolone, lincosamide, macrolide, pleuromutilin, phenicol, and tetracycline classes for 210 M. bovis isolates collected from 1978 to 2009. The MIC₅₀ values of the various antimicrobials were also compared. The MIC₅₀ levels for enrofloxacin and danofloxacin remained low (0.25 μg/mL) across all 3 decades. MIC₅₀ levels for tetracyclines, tilmicosin, an

SUBMITTER: Cai HY 

PROVIDER: S-EPMC6318825 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature