Comparison of DNA methylation profiles associated with spontaneous preterm birth in placenta and cord blood.

ABSTRACT:

Background

The etiology and mechanism of spontaneous preterm birth (sPTB) are still unclear. Accumulating evidence has documented that various environmental exposure scenarios may cause maternal and fetal epigenetic changes, which initiates the focus on whether epigenetics can contribute to the occurrence of sPTB. Therefore, we conducted the current study to examine and compare the DNA methylation changes associated with sPTB in placenta and cord blood.

Methods

This hospital-based case-control study was carried out at three Women and Children's hospitals in South China, where 32 spontaneous preterm births and 16 term births were recruited. Genome-wide DNA methylation profiles of the placenta and cord blood from these subjects were measured using the Illumina HumanMethylation

SUBMITTER: Wang XM 

PROVIDER: S-EPMC6318854 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature