Galectin-3 enhances monocyte-derived macrophage efferocytosis of apoptotic granulocytes in asthma.

ABSTRACT:

Background

Galectin-3 is a 32 kDa protein secreted by macrophages involved in processes such as cell activation, chemotaxis and phagocytosis. Galectin-3 has previously been shown to improve the ability of airway macrophages to ingest apoptotic cells (efferocytosis) in chronic obstructive pulmonary disease (COPD) and may be of interest in non-eosinophilic asthma (NEA) which is also characterised by impaired efferocytosis. It was hypothesised that the addition of exogenous galectin-3 to monocyte-derived macrophages (MDMs) derived from donors with NEA would enhance their ability to engulf apoptotic granulocytes.

Methods

Eligible non-smoking adults with asthma (n = 19), including 7 with NEA and healthy controls (n = 10) underwent a clinical assessment, venepuncture and sputum in

SUBMITTER: Erriah M 

PROVIDER: S-EPMC6318889 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature