A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response.

ABSTRACT: Human tauopathies including Alzheimer's disease, progressive supranuclear palsy and related disorders, are characterized by deposition of pathological forms of tau, synaptic dysfunction and neuronal loss. We have previously identified a pathogenic C-terminal tau fragment (Tau35) that is associated with human tauopathy. However, it is not known how tau fragmentation affects critical molecular processes in cells and contributes to impaired physiological function. Chinese hamster ovary (CHO) cells and new CHO cell lines stably expressing Tau35 or full-length human tau were used to compare the effects of disease-associated tau cleavage on tau function and signaling pathways. Western blots, microtubule-binding assays and immunofluorescence labeling were used to examine the effects of Tau35 on t

SUBMITTER: Guo T 

PROVIDER: S-EPMC6318896 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature