Alterations in Schizophrenia-Associated Genes Can Lead to Increased Power in Delta Oscillations.

ABSTRACT: Genome-wide association studies have implicated many ion channels in schizophrenia pathophysiology. Although the functions of these channels are relatively well characterized by single-cell studies, the contributions of common variation in these channels to neurophysiological biomarkers and symptoms of schizophrenia remain elusive. Here, using computational modeling, we show that a common biomarker of schizophrenia, namely, an increase in delta-oscillation power, may be a direct consequence of altered expression or kinetics of voltage-gated ion channels or calcium transporters. Our model of a circuit of layer V pyramidal cells highlights multiple types of schizophrenia-related variants that contribute to altered dynamics in the delta-frequency band. Moreover, our model predicts that the sa

SUBMITTER: Maki-Marttunen T 

PROVIDER: S-EPMC6319172 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature