Person-Based Brain Morphometric Similarity is Heritable and Correlates With Biological Features.

ABSTRACT: The characterization of the functional significance of interindividual variation in brain morphometry is a core aim of cognitive neuroscience. Prior research has focused on interindividual variation at the level of regional brain measures thus overlooking the fact that each individual brain is a person-specific ensemble of interdependent regions. To expand this line of inquiry we introduce the person-based similarity index (PBSI) for brain morphometry. The conceptual unit of the PBSI is the individual person's brain structural profile which considers all relevant morphometric measures as features of a single vector. In 2 independent cohorts (total of 1756 healthy participants), we demonstrate the foundational validity of this approach by affirming that the PBSI scores for subcortical volum

SUBMITTER: Doucet GE 

PROVIDER: S-EPMC6319174 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature